Grandmother's Accidental Sertraline Overdose Sparks Warnings Over Lethal Risks of Common Antidepressant

A grandmother's accidental overdose on a widely prescribed antidepressant has sparked urgent warnings from medical experts, as an inquest revealed the drug's lethal potential when misused.

Grace Uludag, 55, died at her home in Kent last November after falling and hitting her head following dizziness and shortness of breath. Toxicology tests found 1.94 milligrams of sertraline per litre of blood, exceeding the 1.5 milligram threshold linked to fatal outcomes. The coroner ruled her death an accidental overdose, stressing no suicidal intent was present.

Sertraline, sold as Lustral in the UK and Zoloft in the US, is one of the most commonly prescribed SSRIs. Over 24.4 million prescriptions were issued in England in 2024 alone. The drug is typically taken at 50mg daily, with a maximum recommended dose of 200mg. Symptoms of overdose include nausea, tremors, and cardiac arrest, with severe cases risking serotonin syndrome—a potentially fatal condition.

The NHS has issued warnings about dangerous drug interactions, such as combining SSRIs with triptans, tramadol, or St John's wort. These can trigger serotonin syndrome, causing confusion, hallucinations, and even suicidal thoughts. Doctors emphasize that while sertraline is generally safe when used as prescribed, abrupt cessation can lead to withdrawal symptoms, and long-term use may alter weight, heart rate, or cholesterol.

The tragedy has raised alarms about the drug's side effects, including severe libido suppression. Scottish singer Lewis Capaldi openly discussed this in 2023, describing how sertraline left him 'sexless.' The drug has even been tested on sex offenders to curb impulses, highlighting its powerful effects.

Ms Uludag's family expressed confusion over the overdose, questioning whether her dose was too high. 'She wanted to feel better. She did not expect any of this,' her daughter said. The coroner's report underscores the need for clearer guidelines on SSRI risks, as highlighted by a 2023 Lancet study showing variations in medication impacts.

Health authorities urge patients to avoid self-medicating or altering doses without medical supervision. The case has reignited debates about balancing mental health treatment with the risks of overprescription, as communities grapple with the unintended consequences of a drug trusted by millions.